AustralieFrV1, Main, Exploration, bibRecord, 004F23

Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language

Identifieur interne : 004F23 ( Main/Exploration ); précédent : 004F22; suivant : 004F24

Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language

Auteurs : Giovanni Passalacqua [Italie] ; Carlos E. Baena-Cagnani [Argentine] ; Jean Bousquet [France] ; Giorgio Walter Canonica [Italie] ; Thomas B. Casale [États-Unis] ; Linda Cox [Australie] ; Stephen R. Durham [Royaume-Uni] ; Desiréé Larenas-Linnemann [Mexique] ; Dennis Ledford [États-Unis] ; Ruby Pawankar [Japon] ; Paul Potter [Afrique du Sud] ; Nelson Rosario [Brésil] ; Dana Wallace [États-Unis] ; Richard F. Lockey [États-Unis]

Source :

Journal of allergy and clinical immunology [ 0091-6749 ] ; 2013.

RBID : Pascal:13-0240265

Descripteurs français

Pascal (Inist)
- Désensibilisation, Grade histologique, Effet secondaire, Voie sublinguale, Appareil respiratoire, Langage, Toxicité, Immunologie, Immunopathologie.
Wicri :
- topic : Langage, Immunologie.

English descriptors

KwdEn :
- Desensitization, Histological grading, Immunology, Immunopathology, Language, Respiratory system, Secondary effect, Sublingual administration, Toxicity.

Abstract

Sublingual immunotherapy (SLIT) is increasingly used worldwide. Despite its safety being well ascertained, there is no universally accepted system to grade and classify its adverse events (AEs). According to the literature, it seems reasonable to classify and grade systemic side effects by using the previously published World Allergy Organization recommendations. On the other hand, local side effects are the most frequent with SLIT, sometimes leading to its discontinuation. Therefore grading of the severity of local side effects was perceived as necessary for the purpose of uniform reporting, classification, and quantification of this aspect. A World Allergy Organization Taskforce, after examining the available literature and the postmarketing surveillance data, proposed a clinically based grading of the severity of local AEs caused by SLIT. The use of the Medical Dictionary for Regulatory Activities nomenclature for AEs was also included in this context. The proposed grading system for SLIT-induced local reactions is expected to improve and harmonize surveillance and reporting of the safety of SLIT.

Affiliations:

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Le document en format XML

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<term>Respiratory system</term>
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<term>Sublingual administration</term>
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<term>Immunologie</term>
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<front><div type="abstract" xml:lang="en">Sublingual immunotherapy (SLIT) is increasingly used worldwide. Despite its safety being well ascertained, there is no universally accepted system to grade and classify its adverse events (AEs). According to the literature, it seems reasonable to classify and grade systemic side effects by using the previously published World Allergy Organization recommendations. On the other hand, local side effects are the most frequent with SLIT, sometimes leading to its discontinuation. Therefore grading of the severity of local side effects was perceived as necessary for the purpose of uniform reporting, classification, and quantification of this aspect. A World Allergy Organization Taskforce, after examining the available literature and the postmarketing surveillance data, proposed a clinically based grading of the severity of local AEs caused by SLIT. The use of the Medical Dictionary for Regulatory Activities nomenclature for AEs was also included in this context. The proposed grading system for SLIT-induced local reactions is expected to improve and harmonize surveillance and reporting of the safety of SLIT.</div>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language

Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language

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